Imagine that you receive a preliminary warning of how likely you are to die, along with advice on what you can do to prevent it.
This is the power of genome sequencing. And even if rapidly evolving technology doesn’t make you immortal, it could help us all live healthier lives.
By knowing not only whether a patient is likely to develop diabetes or cancer, but also what drugs will be most effective for their DNA-based recovery, doctors will have the power to change the way they deliver health care.
Home DNA testing is now available in the Dh999 ($ 272) saliva collection kit provided by Dante Labs ‘Genetic for Everybody’ project.
After collection at the Silicon Oasis Laboratory, the DNA contained in saliva is analyzed to produce a complete report.
The results can determine the body’s predispositions, from potential disease to muscle and bone constitution.
The comprehensive analysis provides a clear view of metabolic and traumatic susceptibility, food intolerances and even the most appropriate skin care routine, wrapped in a unique genetic profile.
Andrea Riposati, CEO of Dante Genomics, said the technology has the potential to transform healthcare.
“Genomics is at a similar stage as when the Internet was first launched,” he said.
“It simply came to our notice then. The beauty of genomics turns science into individual benefits and saving lives.
“It can personalize how we eat and train and adapt our lives to live longer and healthier lives. People can use genomics not when they are sick, but before they get sick. ”
The $ 6 million lab, which opened in January, has the capacity to analyze up to 1,000 samples per week, but currently processes about 300.
Saliva kits instruct the user to brush their teeth, then wait 30 minutes without food, drink or smoking before spitting into the tube.
By shaking the tube, it is mixed with the buffer solution, then placed in the enclosed return box and collected by e-mail.
When the sample arrives at the laboratory, DNA extraction begins in a sequencing room known to technicians as the “Temple.” This is where the magic happens.
The DNA sample is converted into data, with one genome providing about 19 gigabytes of genetic information.
The supercomputer analyzes this data and generates a report in a minute, creating a map of human genetic health or biomarkers that could signal a warning signal for a potential disease.
The results are compiled into a report and securely returned via encrypted email within two to four weeks.
“The challenge is to turn this vast amount of genomic data into genomic information that is easy to understand but also scientifically proven,” said Mr Riposati.
“You don’t have to be a doctor to interpret the results.”
“Currently, people visit doctors when they are ill, and it may be too late in some cases.
“This kind of test is like insurance.” Because doctors know which medications you will respond to well, they will have a clearer course of treatment.
“It’s about gaining a better knowledge of your own health.”
Data is securely stored and anonymous
The data is encrypted and anonymized, with personal information separated from the genetic data in a separate database, so there is no chance of identification.
Genomic sequencing and DNA extraction could solve one of the greatest puzzles facing humanity – how to deal with antimicrobial resistance.
With knowledge of the antibiotics that someone is most likely to respond to, doctors can provide the most effective treatment – rather than spinning around in the hopes of finding an antibiotic that will destroy the bacterial infection.
Genes control the production of enzymes that metabolize drugs when we are sick. These enzymes affect how effective the medicine may be or what side effects may occur.
Our unique genotype reveals the volume of enzymes produced to break down drugs so that they can be more easily absorbed.
This is just one of the many ways in which genetic information can be used to improve health care decisions.
In April, Dante Labs was selected as a genetic testing provider for the Abu Dhabi Stem Cells Center (ADSCC), where researchers will focus on cell therapy and regenerative medicine.
A joint program has been developed to develop an mRNA vaccine platform to identify different cancer treatments.
Emirate Genome Program
The National Emirate’s Genome Program is one of the most ambitious in the world.
It examines Emirates’ genetic makeup using DNA sequencing and artificial intelligence to create comprehensive, high-quality genomic data.
The resulting reference genome will pave the way for more personalized and preventive healthcare provision for UAE citizens.
Sequencing takes place at the G42 Healthcare Omics Center of Excellence in Masdar City.
“We are seeing the Emirates become more of a superpower and a global center for this kind of research,” said Mr Riposati.
“Over the last 18 months, sequencing different Covid variants has really brought genomics to the forefront.
“People reacted differently to Covid and to vaccines, which showed how our genetic makeup affects the way we respond to different triggers.”
Updated: June 23, 2022, 5:16 AM